Louise J Brown 

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 Nature nanotech  protein science cover



      • Jiang L, Phang JM, Yu J, Harrop SJ, Sokolova AV, Duff AP, Wilk KE, Alkhamici H, Breit SN, Valenzuela SM (2014) CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: A smoking gun? Biochimica et Biophysica Acta (BBA)-Biomembranes 1838: 643-657.
      • Getts DR, Terry RL, Getts MT, Deffrasnes C, Müller M, van Vreden C, Ashhurst TM, Chami B, McCarthy D, Wu H (2014) Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles. Science translational medicine 6: 219ra217-219ra217.
      • Cordina NM, Liew CK, Potluri PR, Curmi PM, Fajer PG, Logan TM, Mackay JP, Brown LJ (2015) Ca2+ induced PRE-NMR changes in the troponin complex reveal the possessive nature of the cardiac isoform for its regulatory switch. PLOS ONE 10.1371/journal.pone.0112976


      • Valenzuela SM, Alkhamici H, Brown LJ, Almond OC, Goodchild SC, Carne S, Curmi PM, Holt SA, Cornell BA (2013) Regulation of the Membrane Insertion and Conductance Activity of the Metamorphic Chloride Intracellular Channel Protein CLIC1 by Cholesterol. PLOS ONE 8: e56948.
      • Geiselmann M, Juan ML, Renger J, Say JM, Brown LJ, de Abajo FJG, Koppens F, Quidant R (2013) Three-dimensional optical manipulation of a single electron spin. Nature nanotechnology 8: 175-179.
      • Cordina NM, Liew CK, Gell DA, Fajer PG, Mackay JP, Brown LJ (2013) Effects of calcium binding and the hypertrophic cardiomyopathy mutation A8V on the dynamic equilibrium between closed and open conformations of the regulatory N-domain of isolated cardiac Troponin C. Biochemistry 52: 1950-1962
      • Blaber SP, Hill CJ, Webster RA, Say JM, Brown LJ, Wang S-C, Vesey G, Herbert BR (2013) Effect of labeling with iron oxide particles or nanodiamonds on the functionality of adipose-derived mesenchymal stem cells. PloS one 8: e52997.
      • Averaimo S, Abeti R, Savalli N, Brown LJ, Curmi PM, Breit SN, Mazzanti M (2013) Point Mutations in the Transmembrane Region of the Clic1 Ion Channel Selectively Modify Its Biophysical Properties. PloS one 8: e74523.


      • Say JM, Bradac C, Gaebel T, Rabeau JR, Brown LJ (2012) Processing 15-nm Nanodiamonds Containing Nitrogen-vacancy Centres for Single-molecule FRET. Australian Journal of Chemistry 65: 496-503.
      • Jiang L, Salao K, Li H, Rybicka JM, Yates RM, Luo XW, Shi XX, Kuffner T, Tsai VW-W, Husaini Y (2012) Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification. Journal of cell science 125: 5479-5488.
      • Geiselmann M, Juan M, Renger J, Say JM, Brown LJ, de Abajo F, Koppens F, Quidant R (2012) 3D optical manipulation of a single electron spin. arXiv preprint arXiv:12070650.
      • Gaebel T, Bradac C, Chen J, Say J, Brown L, Hemmer P, Rabeau J (2012) Size-reduction of nanodiamonds via air oxidation. Diamond and Related Materials 21: 28-32.
      • Cordina NM, Liew CK, Gell DA, Fajer PG, Mackay JP, Brown LJ (2012) Interdomain orientation of cardiac Troponin C characterized by paramagnetic relaxation enhancement NMR reveals a compact state. Protein Science 21: 1376-1387.



      • Qiu MR, Jiang L, Matthaei KI, Schoenwaelder SM, Kuffner T, Mangin P, Joseph JE, Low J, Connor D, Valenzuela SM (2010) Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene. genesis 48: 127-136.
      • Littler DR, Harrop SJ, Goodchild SC, Phang JM, Mynott AV, Jiang L, Valenzuela SM, Mazzanti M, Brown LJ, Breit SN (2010) The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins? FEBS letters 584: 2093-2101.
      • Littler D, Brown L, Breit S, Perrakis A, Curmi P (2010) Structure of human CLIC3 at 2 Å resolution. Proteins: Structure, Function, and Bioinformatics 78: 1594-1600.
      • Goodchild SC, Howell MW, Littler DR, Mandyam RA, Sale KL, Mazzanti M, Breit SN, Curmi PM, Brown LJ (2010) Metamorphic response of the CLIC1 chloride intracellular ion channel protein upon membrane interaction. Biochemistry 49: 5278-5289.
      • Bradac C, Gaebel T, Naidoo N, Sellars M, Twamley J, Brown L, Barnard A, Plakhotnik T, Zvyagin A, Rabeau J (2010) Observation and control of blinking nitrogen-vacancy centres in discrete nanodiamonds. Nature nanotechnology 5: 345-349.


      • Goodchild SC, Howell MW, Cordina NM, Littler DR, Breit SN, Curmi PM, Brown LJ (2009) Oxidation promotes insertion of the CLIC1 chloride intracellular channel into the membrane. European Biophysics Journal 39: 129-138.


      • Littler DR, Harrop SJ, Brown LJ, Pankhurst GJ, Mynott AV, Luciani P, Mandyam RA, Mazzanti M, Tanda S, Berryman MA (2008) Comparison of vertebrate and invertebrate CLIC proteins: The crystal structures of Caenorhabditis elegans EXC‐4 and Drosophila melanogaster DmCLIC. Proteins: Structure, Function, and Bioinformatics 71: 364-378.


< 2006

      • Littler DR, Assaad NN, Harrop SJ, Brown LJ, Pankhurst GJ, Luciani P, Aguilar MI, Mazzanti M, Berryman MA, Breit SN (2005) Crystal structure of the soluble form of the redox‐regulated chloride ion channel protein CLIC4. FEBS journal 272: 4996-5007.
      • Oakley CE, D HAMBLY B, CURMI PM, BROWN LJ (2004) Myosin binding protein C: structural abnormalities in familial hypertrophic cardiomyopathy. Cell research 14: 95-110.
      • Littler DR, Harrop SJ, Fairlie WD, Brown LJ, Pankhurst GJ, Pankhurst S, DeMaere MZ, Campbell TJ, Bauskin AR, Tonini R (2004) The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition. Journal of Biological Chemistry 279: 9298-9305.
      • Brown LJ, Singh L, Sale KL, Yu B, Trent R, Fajer PG, Hambly BD (2002) Functional and spectroscopic studies of a familial hypertrophic cardiomyopathy mutation in Motif X of cardiac myosin binding protein-C. European Biophysics Journal 31: 400-408.
      • Brown LJ, Sale KL, Hills R, Rouviere C, Song L, Zhang X, Fajer PG (2002) Structure of the inhibitory region of troponin by site directed spin labeling electron paramagnetic resonance. Proceedings of the National Academy of Sciences 99: 12765-12770.
      • Brown LJ, Klonis N, Sawyer WH, Fajer PG, Hambly BD (2001) Independent movement of the regulatory and catalytic domains of myosin heads revealed by phosphorescence anisotropy. Biochemistry 40: 8283-8291.
      • Worthington RA, Brown L, Jellinek D, Chang ACM, Reddel RR, Hambly BD, Barden JA (1999) Expression and localisation of stanniocalcin 1 in rat bladder, kidney and ovary. Electrophoresis 20: 2071-2076.
      • Palm T, Sale K, Brown L, Li H, Hambly B, Fajer PG (1999) Intradomain distances in the regulatory domain of the myosin head in prepower and postpower stroke states: fluorescence energy transfer. Biochemistry 38: 13026-13034.
      • Huang W, Wilson GJ, Brown LJ, Lam H, Hambly BD (1998) EPR and CD spectroscopy of fast myosin light chain conformation during binding of trifluoperazine. European Journal of Biochemistry 257: 457-465.
      • Brown L, Yin JL, Hambly B (1998) Direct cloning of polymerase chain reaction products into the pinpoint Xa1‐T vector protein expression system. Electrophoresis 19: 860-866.
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